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Projects
Contribution
to the following scientific projects:
FBN-projects
Projects
in cooperation with Manfred
Schwerin, Ronald M.
Brunner,
Ute Dorroch, Rosemarie
Weikard,
and Christa Kuehn
Chromosomal
mapping
of selected DNA sequences and elucidation of the chromosome
organization
in the genome
The
chromosomal localization of DNA sequences is one of the important
basics
for the representation of relevant synteny and linkage groups in animal
breeding. The comparative mapping of selected genes or DNA sequences
enabled
e.g. the identification of putative candidate genes in regions of
mapped
QTL and contributes to the elucidation of the genome evolution.
Additionally,
the specific marking of defined chromosome regions enabled the analysis
of the chromosome structure, e.g. of meiotic recombination processes or
the identification of chromosomal rearrangements.
Specific
areas of Research:
- Physical
mapping of selected DNA sequences of laboratory and farm animals by in
situ hybridization methods.
- Generation
of comparative gene maps for specific chromosome regions linked to
economical
traits.
- Identification
and mapping of chromosome fragment specific DNA sequences and different
expressed sequence tags (ESTs).
ADR-Research
Project:
Development of techniques and methods for high resolution mapping of
QTL
and for the application of trait associated markers for the marker
assisted
selection in farm animal breeding
Project
in cooperation with Manfred
Schwerin (FBN), E.
Kalm (Uni Kiel), Rudi
Fries (TU Muenchen)
- Contribution
to the partial project: Development and application of techniques for
the
targeted generation of chromosome fragment specific DNA markers
Generation
of high
resolution species specific and comparative gene maps for specific
chromosome
regions in cattle and human
Project
in cooperation with the James
E. Womack, TAMU, TX, USA, Manfred
Schwerin
- Establishment
of chromosome fragment specific high resolution marker maps in
cattle.
- Comparative
mapping of chromosomal regions in human and cattle or other species
using
a bovine 5000 and 12000 rad WGRH panel.
- Chromosomal
assignment of differentially expressed DNA-sequences (ESTs) in cattle
using
FISH and RH mapping methods
Trypanotolerance
in African cattle
Project
in cooperation with Olivier
Hanotte, ILRI, Kenya, Manfred
Schwerin
- Generation
of chromosome fragment specific DNA libraries covering QTL's for
trypanotolerance
using the method of microdissection
- Chromosomal
assignment of trypanotolerance associated candidate genes and DNA
sequences
by FISH
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