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Forschungsinteresse

Arbeitsgruppe Genregulation

Adresse

Dr. Jens Vanselow

Leibniz-Institut für Nutztierbiologie (FBN)
Forschungsbereich Molekularbiologie

Wilhelm-Stahl-Allee 2
D-18196 Dummerstorf, Germany

Tel: +49/38208-68706
Fax: +49/38208-68702
e-mail: vanselow@fbn-dummerstorf.de

Publikationen

Fürbass R, Tomek W, Vanselow J. 2010. Upstream Stimulating Factors 1 and 2 Enhance Transcription from the Placenta-Specific Promoter 1.1 of the Bovine Cyp19 Gene. BMC Molecular Biology 11:5.

Vanselow J, Spitschak M, Nimz M, Furbass R. 2010. DNA Methylation Is Not Involved in Preovulatory Down-Regulation of CYP11A1, HSD3B1, and CYP19A1 in Bovine Follicles But May Play a Role for Permanent Silencing of CYP19A1 in Large Granulosa Lutein Cells. Biol Reprod 82:289-98.

Nimz M, Spitschak M, Schneider F, Furbass R, Vanselow J. 2009. Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids. Domest Anim Endocrinol 37:45-54.

Fürbass R, Selimyan R, Vanselow J. 2008. DNA methylation and chromatin accessibility of the proximal Cyp19 promoter region 1.5/2 correlate with expression levels in sheep placentomes. Mol Reprod Dev 75:1-7.

Tiemann U, Brüssow KP, Dänicke S, Vanselow J. 2008. Feeding of pregnant sows with mycotoxin contaminated diets has no effect on fetal and maternal hepatic transcription of genes of the insulin-like growth factor system. Food, Additives and Contaminants. In Press.

Vanselow J, Fürbass R, Tiemann U. 2008. Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes. Placenta 29:531-538.

Vanselow J, Selimyan R, Fürbass R. 2008. DNA methylation of placenta-specific Cyp19 promoters of cattle and sheep. Exp Clin Endocrinol Diabetes 116:437-442.

Vanselow J, Nürnberg G, Koczan D, Langhammer M, Thiesen HJ, Reinsch N. 2008. Expression profiling of a high-fertility mouse line by microarray analysis and qPCR. BMC Genomics 9:307.

Nausch N, Manteuffel G, Vanselow J. 2007. 0.2kb promoter sequence of the murine Cyp19 gene target beta-galactosidase expression to specific brain areas of transgenic mice. J Steroid Biochem Mol Biol 103:119-128.

Spitschak M, Langhammer M, Schneider F, Renne U, Vanselow J. 2007. Two high-fertility mouse lines show differences in component fertility traits after long-term selection. Reproduction, Fertility and Development 19:815-821.

Tiemann U, Schneider F, Vanselow J, Tomek W. 2007. In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: Effects on the biosynthesis of reproductive steroid hormones. Reprod Toxicol 24:317-325.

Alm H, Brüssow KP, Torner H, Vanselow J, Tomek W, Dänicke S, Tiemann U. 2006. Influence of Fusarium-toxin contaminated feed on initial quality and meiotic competence of gilt oocytes. Reprod Toxicol 22:44-50.

Pöhland R, Lenz S, Vanselow J, Tomek W. 2006. Detection of gene expression and enzyme activity of Cytochrom P450 arom (aromatase) in preantral and early antral bovine follicles depending on culture conditions in vitro. Archives of Animal Breeding 49:29-40.

Vanselow J, Yang W, Herrmann J, Zerbe H, Schuberth HJ, Petzl W, Tomek W, Seyfert HM. 2006. DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis. J Mol Endocrinol 37:463-477.

Hamel M, Vanselow J, Nicola ES, Price CA. 2005. Androstenedione Increases Cytochrome P450 Aromatase Messenger Ribonucleic Acid Transcripts in Non-Luteinizing Bovine Granulosa Cells. Mol Reprod Dev 70:175-183.

Vanselow J, Pöhland R, Fürbaß R. 2005. Promoter 2 derived Cyp19 expression in bovine granulosa cells coincides with gene-specific DNA hypo-methylation. Mol Cell Endocrinol 233:57-64.

Lenz S, Pöhland R, Becker F, Vanselow J. 2004. Expression of the bovine Aromatase Cytochrome P450 gene (Cyp19) is primarily regulated by promoter 2 in bovine follicles and by promoter 1.1 in corpora lutea. Mol Reprod Dev 67:406-413.

Vanselow J, Fürbaß R, Rehbock F, Klautschek G, Schwerin M. 2004. Cattle and Sheep Use Different Promoters to Direct the Expression of Aromatase Cytochrome P450 Encoding Gene, Cyp 19, during Pregnancy. Dom Anim Endocrinol 27:99-114.

Walzel H, Brock J, Pöhland R, Vanselow J, Tomek W, Schneider F, Tiemann U. 2004. Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro. Glycobiology 14:871-881.

Golovine K, Schwerin M, Vanselow J. 2003. Three different promoters control expression of the Aromatase Cytochrome P450 Gene (Cyp19) in mouse gonads and brain. Biol Reprod 68:978-984.

Tiemann U, Tomek W, Schneider F, Vanselow J. 2003. Effects of the mycotoxins alpha- and beta-zearalenol on regulation of progesterone synthesis in cultured granulosa cells from porcine ovaries. Reprod Toxicol 17:673-681.

Zsolnai A, Anton I, Fésüs L, Estonba A, Schwerin M, Vanselow J. 2002. Allele distributions of two novel SNPs within the sheep Cyp19 gene. J Animal Breeding and Genetics 119:402-405.

Fürbaß R, Said HM, Schwerin M, Vanselow J. 2001. Chromatin structure of the bovine Cyp19 promoter 1.1: DNaseI hypersensitive sites and DNA hypomethylation correlate with placental expression. Eur J Biochem 268:1222-1227.

Lottmann H, Vanselow J, Hessabi B, Walther R. 2001. The tet-on system in transgenic mice - inhibition of the mouse pdx-1-gene activity by antisense-RNA expression in pancreatic beta-cells. J Mol Med 79:321-328.

Rehfeldt C, Kühn G, Vanselow J, Furbass R, Fiedler I, Nurnberg G, Clelland K, Stickland C, Ender K. 2001. Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs. Cell Tissue Res 306:429-440.

Vanselow J, Fürbaß R, Zsolnai A, Kalbe C, Said HM, Schwerin M. 2001. Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep. J Steroid Biochemistry and Molecular Biology 79:279-288.

Fürbaß R, Kalbe C, Zsolnai A, Schwerin M, Vanselow J. 2000. Expression of the aromatase encoding gene in cattle and sheep. Reprod Dom Anim 35:172-173.

Kalbe C, Fürbaß R, Schwerin M, Vanselow J. 2000. Cis-acting elements regulating the placenta-specific promoter of the bovine Cyp19 gene. J Molecular Endocrinol 25:265-273.

Schmidt P, Kühn Ch, Kang´a S, Hanotte O, Vanselow J, Anton I, Langner Ch, Schwerin M. 2000. Interleukin-12 p35 encoding gene of cattle and sheep harbours a polymorphic T stretch in intron 4. Anim Genet 31:283-285.

Vanselow J, Kühn Ch, Fürbaß R, Schwerin M. 2000. Isolation of the bovine Cyp19 promoter 1.2 and identification of genetic variants. Anim Genet 31:337-338.

Goldammer T, Brunner RM, Vanselow J, Zsolnai A, Fürbaß R, Schwerin M. 1999. Assignment of the bovine aromatase encoding gene CYP19 to 10q26 in goat and 7q24-q31 in sheep. Cytogenet Cell Genet 85:258-259.

Vanselow J, Kühn Ch, Fürbaß R, Schwerin M. 1999. Three PCR/RFLPs identified in the promoter region 1.1 of the bovine aromatase gene (CYP19). Anim Genet 30:232-233.

Vanselow J, Zsolnai A, Fésüs L, Schmidt P, Schwerin M. 1999. A Bsp143I PCR-RFLP in exon 3 of the ovine aromatase gene (CYP19). Anim Genet 30:402-403.

Brunner RM, Goldammer T, Fürbaß R, Vanselow J, Schwerin M. 1998. Genomic organization of the bovine aromatase encoding gene and a homologous pseudogene as revealed by DNA fiber FISH. Cytogenet Cell Genet 82:37-40.

Fürbaß R, Kalbe C, Vanselow J. 1997. Tissue-specific expression of the bovine aromatase encoding gene uses multiple transcriptional start sites and alternative first exons. Endocrinology 138:2813-2819.

Fürbaß R, Vanselow J. 1995. An aromatase pseudogene is transcribed in the bovine placenta. Gene 154:287-292.

Schwerin M, Brockmann G, Vanselow J, Seyfert H-M. 1995. Perspectives of molecular genome analysis in livestock improvement - an overview. Animal Research and Development 42:14-26.

Vanselow J, Fürbaß R. 1995. Novel aromatase transcripts from bovine placenta contain repeated sequence motifs. Gene 154:281-286.

Goldammer T, Guérin G, Brunner RM, Vanselow J, Fürbaß R, Schwerin M. 1994. Chromosomal mapping of the bovine aromatase gene (cyp19) and an aromatase pseudogene to chromosome 10 and syntenic group U5. Mammalian Genome 5:822-823.

Vanselow J, Grabczyk E, Jiang P, Baetscher M, Teng S, Fishman MC. 1994. GAP-43 transgenic mice: dispersed genomic sequences confer a GAP-43-like expression pattern during development and regeneration. J Neurosci 14(2):499-510.

Thanos S, Vanselow J, Mey J. 1992. Ganglion cells in the juvenile chick retina and their ability to regenerate axons in vitro. Exp Eye Res 54:377-391.

Schlosshauer B, Grauer D, Dütting D, Vanselow J. 1991. Expression of a novel Müller glia specific antigen during development and after optic nerve lesion. Development 111:789-799.

Vanselow J, Müller B, Thanos S. 1991. Regenerating axons from adult chick retinal ganglion cells recognize topographic cues from embryonic central targets. Vis Neurosci 6:569-576.

Thanos S, Vanselow J. 1990. Fetal tectal transplants in the cortex of adult rats become innervated both by retinal ganglion cell axons regenerating through peripheral nerve grafts and by cortical neurons. Restor Neurol Neurosci 2:63-76.

Vanselow J, Schwab ME, Thanos S. 1990. Responses of regenerating rat retinal ganglion cell axons to contacts with central nervous myelin in vitro. Europ J Neurosci 2:121-125.

Vanselow J, Dütting D, Thanos S. 1990. Target dependence of chick retinal ganglion cells during embryogenesis: cell survival and denrdritic development. J Comp Neurol 295:235-247.

Bähr M, Vanselow J, Thanos S. 1989. Ability of adult rat ganglion cells to regrow axons in vitro can be influenced by fibroblast growth factor and gangliosides. Neurosci Letters 96:197-201.

Thanos S, Vanselow J. 1989. Adult retinal ganglion cells retain the ability to regenerate their axons up to several weeks after axotomy. J Neurosci Res 22:144-149.

Thanos S, Vanselow J. 1989. Einfluss der zentralen und peripheren Neuroglia auf die Regeneration des Nervus opticus. Fortschr Ophthalmol 86:172-175.

Thanos S, Bähr M, Barde Y-A, Vanselow J. 1989. Survival and axonal elongation of adult rat retinal ganglion cells: In vitro effects of lesioned sciatic nerve brain derived neurotrophic factor. Europ J Neurosci 1:19-26.

Vanselow J, Thanos S, Godement P, Henke-Fahle S, Bonhoeffer F. 1989. Spatial arrangement of radial glia and ingrowing retinal axons in the chick optic tectum during development. Dev Brain Res 45:15-27.

Bähr M, Vanselow J, Thanos S. 1988. In vitro regeneration of adult rat ganglion cell axons from retinal explants. Exp Brain Res 73:393-401.

Godement P, Vanselow J, Thanos S, Bonhoeffer F. 1987. A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue. d 101:697-713.